Searchable abstracts of presentations at key conferences in endocrinology

ea0090p379 | Endocrine-related Cancer | ECE2023

Association between diabetes mellitus and reduced efficacy of pembrolizumab in non-small cell lung cancer

Leshem Yasmin , Dolev Yardena , Siegelmann-Danieli Nava , Sharman Moser Sarah , Apter Lior , Chodick Gabriel , Nikolaevski-Berlin Alla , Shamai Sivan , Merimsky Ofer , Wolf Ido

Introduction: Type 2 diabetes mellitus (T2DM) and cancer commonly occur together, either because of direct association or merely as both diseases are common among the elderly. The presence of either T2DM itself, or its treatment may affect cancer progression outcomes and response to cancer therapy. Immune-checkpoint inhibitors (ICIs) have become the cornerstone of treatment of several malignancies, including non-small cell lung cancer (NSCLC). As T2DM has been shown to suppres...